Building a Multi-Indication Platform with Cenicriviroc
Our lead product candidate cenicriviroc (CVC) is under evaluation to treat a number of serious illnesses including non-alcoholic steatohepatitis (NASH) and HIV-1
CVC for NASH
NASH is a severe type of non-alcoholic fatty liver disease, or NAFLD, with no approved therapies. NASH affects 3 to 5 percent of the US population and can lead to life-threatening complications such as cirrhosis and liver cancer. Based on safety data from over 550 subjects who have received CVC in Phase 1 and 2 studies and statistically significant improvements in fibrosis in animal models, CVC is being evaluated in patients who have no approved therapies for this chronic disease.
CVC/3TC for HIV-1
Approximately 35 million people worldwide are living with HIV-1 infection and there is no cure. The mainstay of HIV-1 care is lifelong multi-drug therapy, which can be often accompanied toxicity associated with chronic use. CVC as part of a fixed-dose combination with lamivudine (3TC) has the potential to provide a new combination backbone to help address the unmet need for less toxic agents.
Tobira is advancing clinical development programs in NASH and HIV-1.
Tobira is also investigating CVC in other potential indications such as graft versus host disease and certain cancers where an immune-inflammatory cascade leads to either fibrosis or organ failure.